Effect of hematocrit on cyclosporine (cyclosporin A) in whole blood and plasma of renal-transplant patients.
نویسنده
چکیده
Cyclosporine concentrations in whole blood and plasma were determined in 25 samples from renal-transplant patients. The portion of cyclosporine carried in plasma varied widely, from 9 to 58%. Radioimmunoassay and liquid chromatography both revealed a statistically significant inverse correlation between hematocrit and the plasma fraction of cyclosporine in the circulating blood. Regression analysis indicates that a 10% increase in hematocrit would decrease the portion of cyclosporine in plasma by 12 to 14%. Studies with cyclosporine-supplemented samples further demonstrated an effect of hematocrit on the drug concentration in plasma without a corresponding effect on the concentration in whole blood. The distribution of cyclosporine between plasma and erythrocytes was unaffected by plasma cholesterol and triglycerides for these transplant patients.
منابع مشابه
The Efficacy of Amlodipine and Diltiazem in Cyclosporine Dose Adjustment with Respect to Trough and 2-hour Concentrations in Kidney Transplant Patients
Background & Aims: Hypertension, hyperuricaemia and nephrotoxicity are some common side-effects of Cyclosporine A (CsA) treatment in renal transplant recipients. Previous studies suggest that Calcium Channel Blockers (CCB) can increase serum level of CsA and may improve graft function in patients receiving CsA. The aim of this study was to evaluate the effects of Diltiazem and Amlodipine on cyc...
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متن کاملDiltiazem Co-Treatment in Renal Transplant Patients Receiving Cyclosporine with Respect to Concentration at Two Hours (C2)
Cyclosporine (CsA) is a drug that has been used for prevention of kidney transplant rejection for many years. Diltiazem with the inhibition of cyclosporine metabolism and clearance will increase CsA concentration and CsA dose can be decreased. The aim of this study was the evaluation of diltiazem effect on CsA dose adjustment with respect to C2. Forty stable renal transplant p...
متن کاملDistribution of cyclosporin A metabolites among plasma and cells in whole blood: effect of temperature, hematocrit, and metabolite concentration.
Drug-free whole-blood samples supplemented with the cyclosporines and samples from 10 transplant patients receiving cyclosporin A (CsA) were equilibrated at 4, 22, and 37 degrees C for 2.5 h; the plasma and cells were separated; and the fractions were assayed by high-performance liquid chromatography (HPLC). Partitioning of CsA and metabolites among plasma and cells was diverse and not always p...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 31 3 شماره
صفحات -
تاریخ انتشار 1985